Louisville vs. Ole Miss odds, line: 2021 college football picks, Week 1 predictions from model on 57-37 run

The Louisville Cardinals and the Ole Miss Rebels face off in their 2021 season opener on Monday night. The Cardinals struggled last season finishing 12th in the ACC with a 4-7 record. The Rebels were up and down last season finishing the year with a 5-5 record. Ole Miss head coach Lane Kiffin will miss Monday’s matchup after testing positive for COVID-19.

Kickoff from Mercedes-Benz Stadium in Atlanta is set for 8 p.m. ET. The Rebels are 10-point favorites in the latest Louisville vs. Ole Miss odds from Caesars Sportsbook, while the over-under for total points scored is set at 76. Before making any Ole Miss vs. Louisville picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of more than $3,600 for $100 players on its top-rated college football picks against the spread. It also enters Week 1 of the 2021 season on a 57-37 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Louisville vs. Ole Miss. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Ole Miss vs. Louisville:

• Louisville vs. Ole Miss spread: Ole Miss -10
• Louisville vs. Ole Miss over-under: 76 points
• Louisville vs. Ole Miss money line: Louisville +300, Ole Miss -380
• LOU: The total has gone over in 12 of their last 16 games
• MISS: The Rebels are 13-4 in the last 17 games when playing as the favorite 

Why Louisville can cover

Ole Miss struggled mightily on defense last year. The Rebels were the SEC’s worst defense, giving up 38.3 points a game while only recording 16 sacks. The Ole Miss defense allowed 519 yards of total offense, including 206.9 on the ground with 312.1 through the air.

Redshirt junior quarterback Malik Cunningham will look to torch Ole Miss’ defense with both his arm and legs. Cunningham completed 64 percent of his passes for 2,617 yards and 20 passing touchdowns. The Montgomery, Ala., native rushed for 609 yards last season to go along with seven scores. 

Why Ole Miss can cover

The Cardinals failed to win a game on the road last season, going 0-5. Junior quarterback Matt Corral was named the preseason first-team All-SEC quarterback after he had an outstanding sophomore season. Corral completed 70 percent of his passes for 3,337 yards and 29 passing touchdowns.

Corral had seven games over 300-yards passing. The Ventura, Calif., native had a two-game stretch against Vanderbilt and South Carolina where he threw for 925 passing yards to go along with 10 passing touchdowns. With a full offseason under his belt with the Ole Miss staff, expect Corral to have more command of the offense while looking to limit his turnovers. 

How to make Ole Miss vs. Louisville picks

SportsLine’s model is leaning under on the total, projecting the teams to combine for 73 points. The model also says one side of the spread hits in 60 percent of simulations. You can only get the pick at SportsLine. 

So who wins Louisville vs. Ole Miss? And which side of the spread hits in 60 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.