Giants vs. Panthers odds, line, spread, prediction: 2022 NFL picks, Week 2 best bets by model on 139-98 run

An NFC battle features the Carolina Panthers and the New York Giants matching up on Sunday as part of the Week 2 NFL schedule. Head coach Brian Daboll will lead the Giants into MetLife Stadium for the first time, and New York will be energized after securing its first season-opening win since 2016. On the opposite sideline, Carolina fell to the Cleveland Browns, 26-24 in Week 1. 

Kickoff is set for 1 p.m. ET. New York is a 2-point favorite in the latest Panthers vs. Giants odds from Caesars Sportsbook, and the over/under is 43.5. Before making any Giants vs. Panthers picks or bets, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model. 

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated Giants vs. Panthers 10,000 times and just revealed its NFL expert picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Panthers vs. Giants:

• Giants vs. Panthers spread: Giants -2
• Giants vs. Panthers over/under: 43.5 points
• Giants vs. Panthers money line: Carolina +110, New York -130
• CAR: Panthers are 4-1 ATS in their last five games in September
• NYG: Giants are 17-8-1 ATS versus teams with losing records
• Giants vs. Panthers picks: See picks here

Why the Giants can cover

Quarterback Daniel Jones got the ball out quickly and into his playmakers’ hands in the win last week. Jones went 17-for-21 for 188 yards with two passing touchdowns. The Duke product has the athleticism to make plays with his legs as well. He also logged 25 yards on six carries in Week 1.

Receiver Sterling Shepard is a smart and elusive route runner for New York. Shepard has reliable hands with strong footwork to get open. The Oklahoma product led the team in Week 1 with two catches for 71 yards, including a 65-yard touchdown bomb. Receiver Richie James is a shifty weapon in the slot. He played well throughout the summer, impressing the coaching staff, and against Tennessee, he had six catches for 59 yards with three first downs.

Why the Panthers can cover 

Carolina’s defense is filled with fast and instinctive players. They had outstanding athletes at all three levels on this unit. Defensive end Brian Burns is a lethal edge threat with an abundance of moves to find his way into the backfield. Burns uses his quickness and long arms to get past blockers. Linebacker Shaq Thompson is an athletic force in the middle of the defense.

Thompson is superb in the coverage with the awareness to consistently be around the ball. In Week 1, he recorded six total stops. Safety Jeremy Chinn lines up all across the field for Carolina and is a sound tackler with the ability to cover tight ends and running backs. The 2020 second-round pick is always flying around and finished third on the team with seven total tackles.

How to make Panthers vs. Giants picks

The model is leaning Under the total, projecting 40 combined points. The model also has a strong against the spread pick, with one side hitting well over 50% of the time. See which side to back at SportsLine.

So who wins Panthers vs. Giants on Sunday? And which side of the spread cashes well over 50% of the time? Visit SportsLine right now to find out which side of the Giants vs. Panthers spread you should be all over Sunday, all from the model on a 139-98 roll on its top-rated NFL picks.