NFL DFS Thursday Night Football picks: Broncos vs. Colts fantasy lineup advice for DraftKings, FanDuel

Week 5 of the 2022 NFL schedule opens with a matchup between veteran quarterbacks, with Russell Wilson and the Denver Broncos hosting Matt Ryan and the Indianapolis Colts on Thursday Night Football. Wilson and Ryan could be featured more prominently with talented young running backs Javonte Williams (knee) and Jonathan Taylor (ankle) out of the Week 5 TNF NFL DFS player pool. Does the absence of Williams and Taylor make Wilson and Ryan must-start players in your NFL DFS lineups and NFL DFS stacks? Or would it make sense to build your NFL DFS strategy around backup running backs like Melvin Gordon, Nyheim Hines, Deon Jackson, or Phillip Lindsay? Both sides also have wide receivers — Michael Pittman, Jerry Jeudy, and Courtland Sutton — who all project to be impact classic and showdown NFL DFS picks for Thursday Night Football.

Before making any Thursday NFL DFS picks for Colts vs. Broncos on sites like DraftKings and FanDuel of your own, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor. 

Kaylor is an NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

In Week 1 Monday Night Football, Kaylor listed Denver wide receiver Jerry Jeudy as one of his top Showdown DFS picks and the former Alabama star was the highest scoring fantasy player in the game. In Week 2 MNF, Kaylor called for a huge night from Buffalo wide receiver Stefon Diggs and he delivered 12 receptions for 148 yards and three touchdowns. In Week 3 TNF, Kaylor dominated with the Cleveland duo of Amari Cooper and Nick Chubb. He followed that up by jumping all over Dallas wide receiver CeeDee Lamb, who was the highest scorer in the MNF Week 3 game. Then, in Week 4 MNF, his top two picks were 49ers wide receiver Deebo Samuel and Rams wide receiver Cooper Kupp, who both posted massive numbers. 

Now, Kaylor has turned his attention to Broncos vs. Colts on Thursday Night Football Week 5 and locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine.

Top NFL DFS picks for Broncos vs. Colts on TNF

One of Kaylor’s favorite Colts vs. Broncos TNF DFS picks is Denver quarterback Russell Wilson. The 33-year-old quarterback is coming off arguably his best game as a member of the Broncos, and Kaylor expects the Broncos to lean heavily on the player they invested $245 million into this offseason. The Colts have been much better at defending the run than the pass in 2022, and the Broncos have two wide receivers with game-breaking ability in Courtland Sutton and Jerry Jeudy. Wilson is at his best when operating out of play-action, which is exactly what Kaylor expects the Broncos to focus on against the Colts.

“While he hasn’t posted eye-popping numbers with the Broncos, Wilson did show signs of life against the Raiders in Week 4. With Javonte Williams out for the year and Melvin Gordon having ball security issues, it’s hard for me to see Denver leaning too heavily on its rushing attack against Indianapolis. Couple that with Wilson showing more inclination to make plays with his legs in the Broncos’ last two games and you have the makings of a highly productive fantasy night for the future Hall of Famer against the Colts on Thursday Night Football,” Kaylor told SportsLine. You can see the rest of Kaylor’s NFL DFS picks here.

How to make NFL DFS lineups for Colts vs. Broncos on TNF

Kaylor is also targeting another undervalued option that could explode for huge numbers for Thursday Night Football. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of Kaylor’s TNF DFS picks, at SportsLine. 

So who is Jimmie Kaylor including in his optimal NFL DFS lineups for Thursday Night Football? And which under-the-radar DFS picks offer huge value? Visit SportsLine now to see optimal NFL DFS picks, rankings, advice, and stacks, all from a DFS expert who already won a single-game millionaire maker tournament in 2022, and find out.