NFL football pool, pick’em, office pool, confidence picks: Choose the 49ers for Week 1, 2021

There have been times in recent years where it’s felt like the National Football League has eased its way into the regular season, but the powers that be made sure that wasn’t the case when they crafted the Week 1 NFL schedule. The 2021 NFL Kickoff Game pitted the Buccaneers against the Cowboys. On Sunday, we’ll see five games between playoff teams from a season ago and two divisional rivalries. That’s could make filling out your Week 1 NFL office pool picks an enormous challenge.

To make matters worse, oddsmakers are expecting plenty of parity, with no Week 1 NFL spreads higher than 8.5 points at Caesars Sportsbook. Getting off to a strong start with your NFL confidence picks is always critical, so having a little help as you make your Week 1 NFL pool picks could go a long way. Before you make your NFL predictions, you need to see the Week 1 NFL football pool picks from SportsLine’s proven model.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters the 2021 season on an incredible 120-78 run on top-rated NFL picks that dates back to the 2017 season.

More importantly for NFL confidence pool players, the model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports office pool players four times during that span. Anyone who has followed it is way up.

Now, the model has simulated the entire Week 1 2021 NFL schedule 10,000 times and generated its optimal NFL pick’em plays. Go to SportsLine to see them.

Top Week 1 NFL office pool predictions

One of the top Week 1 NFL pick’em predictions from the model: San Francisco cruises past Detroit in a Week 1 matchup. Ford Field hasn’t been well-defended in recent years, with the Lions going 1-7 in their own building in 2020, 2-6 in 2019, and 3-5 in 2018. Meanwhile, the 49ers established themselves as one of the best road teams with a 7-1 record away from home in 2019 and a 5-1 mark last season.

The model is expecting the Lions’ offense to struggle with the transition from Stafford to Jared Goff at quarterback and without anyone ready to replace Kenny Golladay as the true No. 1 receiver. Detroit averages fewer than 325 yards of total offense in SportsLine’s 10,000 simulations of Sunday’s matchup, while the 49ers pile up over 450. The model predicts a 28-19 final score, with San Francisco winning in 70 percent of simulations and also covering the spread in well over 50 percent of simulations.

How to make Week 1 NFL office pool picks

The model also made the call on every other Week 1 game and has strong picks for potentially close matchups like Seahawks vs. Colts and Chiefs vs. Browns. It’s also calling for a Super Bowl contender to go down hard. You can only see all of the model’s NFL pool picks here.

So who should you pick in every Week 1 NFL game? And which Super Bowl favorite goes down hard? Visit SportsLine now to get optimal NFL office pool picks, all from the advanced computer model that has ranked in the Top 10 on straight-up picks four of the last five years and went an outstanding 120-78 last season.