NFL odds, lines, picks, spreads, best bets, predictions for Week 3, 2022: Model loving Bengals, Seahawks

Just one game on the Week 3 NFL schedule features an undefeated team versus a winless team, Chiefs vs. Colts. Yet, you may be surprised to see Kansas City as just a 6.5-point favorite in the Week 3 NFL odds at Caesars Sportsbook. Perhaps no team has looked worse than the Colts thus far, even with Matt Ryan joining Jonathan Taylor in the backfield on a team that won nine games last year. Indianapolis could only muster a tie versus the Texans and was shut out by the Jaguars. Colts vs. Chiefs features one of the largest NFL spreads of the week, but which team is worth backing with your NFL bets? All of the Week 3 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 3 NFL picks now. 

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, it has turned its attention to the latest Week 3 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.

Top Week 3 NFL predictions

One of the model’s strongest Week 3 NFL picks is that the Bengals (-4.5) go on the road and cover against the Jets. Just six teams had fewer sacks than the Jets last year, and they have the same statistical ranking in sacks this year. A lack of pressure on Joe Burrow should allow him to pick apart the Jets’ secondary since New York is allowing opposing quarterbacks a passer rating of over 100 this season. Burrow is projected to top 300 passing yards and also toss multiple touchdown passes, with Ja’Marr Chase having nearly 100 yards in receptions.

The model doesn’t expect any Jets player to top 60 receiving yards. In fact, New York loses by two scores, with the Bengals (-4.5) covering nearly 60 percent of the time.

Another one of the model’s Week 3 NFL predictions: The Seahawks (-2) cover the spread at home versus the Falcons. Seattle failed to cover in its Week 2 loss to San Francisco which ended Geno Smith’s miraculous streak against the spread. Smith had covered in nine straight starts, the second-longest streak by any quarterback since 2000. Even with the defeat, Smith is 9-1 ATS over his last 10 starts and has covered in four of his five career starts for the Seahawks.

The SportsLine model projects Seattle (-2) to win by more than a field goal, and thus, cover well over 50 percent of the time. The model also has 44 combined points being scored and says to back the Over (42). See which other teams to pick here.

How to make Week 3 NFL picks 

The model has also made the call on who wins and covers in every other game on the Week 3 NFL schedule, and it’s calling for a Super Bowl contender to go down hard. You can only get every pick for every game at SportsLine.

So what NFL picks can you make with confidence? And which Super Bowl contender goes down hard? Check out the latest NFL odds below, then visit SportsLine to see which teams win and cover the spread, all from a proven computer model that has returned over $7,000 since its inception, and find out.

Week 3 NFL odds, lines, spreads

Get full NFL picks at SportsLine

Thursday, Sept. 22

Steelers at Browns (-3.5, 40.5)

Sunday, Sept. 25

Chiefs at Colts (+6.5, 47)

Ravens at Patriots (+3, 43.5)

Saints at Panthers (+3, 41)

Texans at Bears (-2.5, 39)

Bills at Dolphins (+4.5, 51)

Lions at Vikings (-7, 53.5)

Bengals at Jets (+4.5, 43)

Raiders at Titans (+1, 45.5)

Eagles at Commanders (+4, 50.5)

Jaguars at Chargers (-7, 48)

Packers at Buccaneers (-3, 44)

Rams at Cardinals (+4, 50.5)

Falcons at Seahawks (-2, 42)

49ers at Broncos (PK, 43)

Monday, Sept. 26

Cowboys at Giants (-3, 39.5)