Ohio State vs. Oregon odds, line: 2021 college football picks, Week 2 predictions from model on 63-45 run

Teams with national championship aspirations face off when the No. 3 Ohio State Buckeyes and No. 12 Oregon Ducks meet in college football‘s marquee Week 2 matchup on Saturday at Ohio Stadium in Columbus, Ohio. The Buckeyes (1-0) have a slew of skill position playmakers one season after reaching the College Football Playoff National Championship Game. They opened the season last week with a 45-31 win at Minnesota. Meanwhile the Ducks (1-0) remain favored to win the Pac-12 title for the third straight year. Their season began with a 31-24 victory against Fresno State. 

Kickoff is set for noon ET. The Buckeyes are 14.5-point favorites in the latest Ohio State vs. Oregon odds from Caesars Sportsbook, while the over-under for total points scored is 64. Before making any Oregon vs. Ohio State picks, check out the college football predictions from the SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past five-plus years, the proprietary computer model has generated a stunning profit of over $3,500 for $100 players on its top-rated college football picks against the spread. It also enters Week 2 of the 2021 season on a 63-45 run on all top-rated college football picks. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Oregon. You can visit SportsLine now to see the picks. Here are the college football odds and trends for Oregon vs. Ohio State:

• Ohio State vs. Oregon spread: Buckeyes -14.5
• Ohio State vs. Oregon over-under: 64 points
• Ohio State vs. Oregon money line: Buckeyes -650, Ducks +450
• OSU: C.J. Stroud leads the country in yards per completion (22.6).
• ORE: Freshman linebacker Justin Flowe is tied for the Pac-12 lead in tackles (13).

Why Ohio State can cover

Ohio State has arguably the best receiving duo in the country in Chris Olave and Garrett Wilson. After combining for 93 receptions, 1,452 yards and 13 touchdowns in just eight games last season, Olave and Wilson were named to the AP preseason All-America first-team and second-team offense, respectively, entering this season. In last week’s season-opening win over the Golden Gophers, the two combined for nine catches for 197 yards and three touchdowns.

In addition, Ohio State has a big-play threat at running back in freshman Miyan Williams. A 5-foot-8, 227-pounder from Cincinnati, Williams ran for a team-high 125 yards, including a 71-yard touchdown, against Minnesota. The score was the longest run by an Ohio State player since Master Teague’s 73-yard TD run at Northwestern in 2019.

Why Oregon can cover

Oregon has a potent running back duo in CJ Verdell and Travis Dye. Both juniors, Verdell and Dye have the most combined career rushing yards (4,501) of any active FBS running back tandem. In the season-opening win over Fresno State, the two combined for 138 rushing yards and two touchdowns on 31 carries.

On Saturday Verdell and Dye will face an Ohio State defense that struggled to stop the run against Minnesota. The Buckeyes coughed up 203 rushing yards and three rushing touchdowns (on 50 carries) to the Golden Gophers. Mohamed Ibrahim had 163 yards and two touchdowns and averaged 5.4 yards per carry before suffering a season-ending lower leg injury.

How to make Oregon vs. Ohio State picks

SportsLine’s model is leaning under on the total, projecting the teams to combine for 57 points. The model also says one side of the spread hits in well over 50 percent of simulations. You can only get the pick at SportsLine. 

So who wins Ohio State vs. Oregon? And which side of the spread hits in well over 50 percent of simulations? Visit SportsLine now to find out which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.