Prisco’s NFL Week 16 picks: Chiefs beat Steelers in one-point thriller, Bills get payback against Patriots

Despite the COVID madness that forced games to be rescheduled, it was a good week for my NFL picks.

I went 11-5 ATS in my expert picks, 12-4 straight up and 3-3 with my Best Bets as part of the Pick-Six Podcast.

That brings my season records to 117-104-3 ATS, 137-86-1 straight up and 49-45 with my best bets.

I’ll take it.

I am still waiting for another triple crown, which would be getting winning records for all three. Let’s hope the holiday fever helps give the picks some good feelings and allows me to give you the triple as a nice gift.

San Francisco 49ers at Tennessee Titans (+3)

The 49ers have turned their season around and they have the look of a playoff team. The Titans are struggling. But this is a tough road trip for the 49ers on a short week against a Tennessee team that is in big-time need of a victory. I think the Titans will do enough on offense to pull this out as their defense will limit San Francisco. 

Pick: Titans 23, 49ers 17

Which NFL picks can you make with confidence, and which Super Bowl contender will go down hard? Visit SportsLine now to see which teams win and cover the spread, all from a proven computer model on a 133-96 roll on NFL picks.

Cleveland Browns at Green Bay Packers (-7.5)

The Browns will get a bunch of guys back off the COVID list this week, but now they face a brutal road game against the Packers. Green Bay held on last week against the Ravens. That won’t be the case here. Look for Green Bay to roll against a Cleveland defense that might be without Myles Garrett.

Pick: Packers 33, Browns 23

Indianapolis Colts at Arizona Cardinals (-1)

The Cardinals are looking to regroup after an embarrassing loss to the Lions where they were outplayed in every area. The Colts beat the Patriots last week with their run game keying the win. I think Arizona will bounce back here and play well as they put the game on Carson Wentz. In that scenario, Arizona gets the best of it. 

Pick: Cardinals 30, Colts 20

New York Giants at Philadelphia Eagles (-10)

The Eagles beat up an undermanned Washington team thanks to a dominating rushing performance, which has become their calling card. The Giants looked bad losing at home last week to Cowboys. The Giants did beat the Eagles three weeks ago. They won’t this time. 

Pick: Eagles 30, Giants 17

Los Angeles Rams at Minnesota Vikings (+3)

This is a bigger game for the Vikings if they are to have any chance to be a playoff team. The Rams are coming off a nice victory over Seattle that saw the defense play well. But the offense wasn’t as crisp. It will be here. But Minnesota will also play well on offense. Look for a lot of points with the Vikings pulling off a home upset. 

Pick: Vikings 30, Rams 28 

Buffalo Bills (+2.5) at New England Patriots

This is essentially for the division title. If the Bills win, they have two winnable games left. If the Patriots win, they pretty much lock up the division. So this will be fun. There won’t be wind like the last meeting, but there could be snow. That favors the better passing team, which is the Bills. I think they get revenge from the wind game and take it behind a good day by Josh Allen.

Pick: Bills 28, Patriots 23

Tampa Bay Buccaneers at Carolina Panthers (+10)

The Bucs are banged up as they come off a shutout loss to the Saints at home. The Carolina defense will present another tough challenge for Tom Brady, especially down his two top receivers. That’s why the Panthers will keep it close. The Bucs will win, but barely.

Pick: Bucs 24, Panthers 20

Jacksonville Jaguars at New York Jets (PK)

This is the dog game of the week, with two teams looking to next year. The Jaguars didn’t get a bump from firing Urban Meyer last week, and now must head out for a road game in the cold. The Jets have shown some fight lately, which will play out here. The Jaguars don’t do enough on offense. 

Pick: Jets 19, Jaguars 14

Detroit Lions at Atlanta Falcons (-5.5)

The Lions impressed in a big way in beating the Cardinals last week. Atlanta blew too many scoring chances in losing to the 49ers. Neither one of these teams is going to the playoffs. Both still compete for first-year coaches and I think the Falcons at home will play better this week in the red area. The Falcons win it. 

Pick: Falcons 30, Lions 24

Los Angeles Chargers at Houston Texans (+10)

The Chargers are coming off a tough home loss to the Chiefs, but they played well in that game. The Texans beat the Jaguars last week, but this is a big step up. The Chargers will be without Joey Bosa, which will hurt. Justin Herbert will get the best of the Texans, but something says the Texans will hang around. 

Pick: Chargers 31, Texans 23

Baltimore Ravens at Cincinnati Bengals (-3)

This is for first place in the AFC North. The Bengals dominated in beating the Ravens in Baltimore earlier this year, with Joe Burrow having a big day. With the Ravens secondary an issue, I think he has another big day here. Lamar Jackson should be back for the Ravens, but the offense has struggled since mid-October. The Bengals are the better team and will show it. 

Pick: Bengals 28, Ravens 23

Chicago Bears at Seattle Seahawks (-6.5)

These two are playing for next year, which means this could be one of Russell Wilson’s last home games. Wilson didn’t play well in losing to the Rams last week. But I think being back home he will bounce back and play well. Justin Fields will have a tough time playing in this environment. The Seahawks take it. 

Pick: Seahawks 27, Bears 20

Pittsburgh Steelers (+7) at Kansas City Chiefs 

The Steelers are pretty much playing for their playoff lives, which won’t be easy against the best team in the AFC. The Chiefs have played great defense the last five games, which will make it a challenge for Ben Roethlisberger. The Chiefs offense has shown signs of coming to life lately, but they could be without Tyreek Hill and Travis Kelce. The Steelers will hang around here, but the Chiefs will win it. 

Pick: Chiefs 24, Steelers 23

Denver Broncos at Las Vegas Raiders (PK)

The Raiders won a tough road game with a schedule change against the Browns, but now must play on a short week. The Broncos will start Drew Lock for the injured Teddy Bridgewater. The Raiders have a chance to be a playoff team, and I think they will play like it here. Raiders take it. 

Pick: Raiders 26, Broncos 19

Washington Football Team at Dallas Cowboys (-11)

Washington should have Taylor Heinicke back off the COVID list here. But this is a tough road game on a short week. That matters. The Cowboys haven’t played well on offense lately, but that will change in this one. Washington gets handled in big way by the Cowboys as Dak Prescott gets back on track. 

Pick: Cowboys 33, Washington 16

Miami Dolphins at New Orleans Saints (-3)

The Dolphins have won six straight to get into the playoff hunt, but the Saints are coming off an impressive shutout of Tom Brady and the Bucs. The defense was outstanding, which will be the case here against Miami. Look for the Saints pass rush to dominate this game. The Saints will do enough on offense to pull this one out. 

Pick: Saints 21, Dolphins 13