Week 15 NFL picks, odds, 2021 best bets from proven model: This five-way parlay pays 25-1

The Bills were a popular pick to win the Super Bowl heading into the 2021 NFL season, but Buffalo enters Week 15 with a 7-6 record after losing to Tom Brady and the Buccaneers in overtime. The Bills sit two games behind the Patriots (9-4) in the AFC East standings and currently hold the seventh and final playoff spot in the AFC playoff picture. The Bills have lost four of their last six, but they’ll look to get back on track when they host the Panthers on Sunday. 

The Week 15 NFL odds from Caesars Sportsbook list the Bills as 11.5-point favorites against the Panthers, who have lost three straight. Buffalo has won five of its last seven meetings against the Panthers, but does that mean the Bills are a good value for your Week 15 NFL bets? Before locking in any Week 15 NFL picks on those games or others, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception six-plus years ago. The model enters Week 15 of the 2021 season on an incredible 132-96 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 15. If you successfully parlay its picks, you’d be looking at a massive payout of 25-1. You can only see the model’s Week 15 NFL picks at SportsLine. 

Top Week 15 NFL picks

After simulating every game 10,000 times, the model is high on the Saints to cover as 11-point underdogs on the road against the Tampa Bay Buccaneers. The Saints have won six of their last seven meetings against Tampa Bay and are 7-3 against the spread in their last 10 games against the Buccaneers. 

New Orleans knocked off Tampa Bay 36-27 earlier this season, and New Orleans will be looking to keep its playoff hopes alive after dominating the Jets last week. In the Saints’ 30-9 victory over New York, quarterback Taysom Hill had a field day with his legs, rushing for 73 yards and two touchdowns while throwing for 175 yards. 

The model is predicting that Hill has another big day against a Tampa Bay defense that just allowed Josh Allen to eclipse 300 passing and 100 rushing yards. Hill is projected to average 5.8 yards per carry while also throwing for 162 yards and one touchdown. Meanwhile, Alvin Kamara is projected to rack-up 99 all-purpose yards, helping the Saints cover the spread in 60 percent of simulations.

How to make Week 15 NFL parlays

The model also jumped on four other matchups where it says the line is way off, including a divisional battle and a game between two teams fighting for their playoff lives. You can only see the model’s NFL Week 15 best bets and parlay at SportsLine. 

What are the model’s top Week 15 NFL picks? And which other NFL matchups should you target for a 25-1 payout? Visit SportsLine now to see the Week 15 NFL best bets from a model on a 132-96 run on its top-rated picks, and find out.