Week 4 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay pays 25-1

The Week 4 NFL schedule features multiple intriguing matchups, including a game between New Orleans and Minnesota in London. New Orleans will try to rebound after losing its second consecutive game last week. Minnesota erased a double-digit deficit in its 28-24 win over Detroit in Week 3, putting the Vikings at 2-1 on the season. They are 2.5-point favorites against the Saints in the latest Week 4 NFL odds at Caesars Sportsbook. Which Week 4 NFL lines should you target with your Week 4 NFL bets? Before you make any Week 4 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season.  

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 4. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 4 NFL picks at SportsLine. 

Top Week 4 NFL picks

After simulating every game 10,000 times, the model is high on the Pittsburgh Steelers (-3.5) to win and cover against the New York Jets on Sunday. Pittsburgh is coming off a pair of disappointing losses to New England and Cleveland, but the Steelers will return home with extra rest to work with on Sunday. They have not played since the Thursday night game in Week 3, which resulted in a 29-17 loss to the Browns. Pittsburgh had the ball down by just six points in the final seconds before Cleveland scored on a fumble return to close the game, making the final score look more lopsided than the game actually was. 

New York has sandwiched its win over Cleveland with a pair of blowout losses to Baltimore and Cincinnati, so the model does not have high hopes for the Jets against another AFC North opponent. Quarterback Joe Flacco threw two interceptions and zero touchdowns in a 27-12 loss to the Bengals last Sunday, while running back Michael Carter rushed for just 39 yards. The model expects New York to struggle again offensively this week, one reason Pittsburgh is covering the spread in almost 60% of simulations. See which other NFL parlay picks to make here.

How to make Week 4 NFL parlays

The model also jumped on four other NFL matchups where it says the line is way off, including backing a pair of underdogs. You can only see the model’s NFL Week 4 best bets and parlay at SportsLine. 

What are the model’s top Week 4 NFL picks? And which other NFL matchups should you target for a strong 25-1 payout? Visit SportsLine now to see the Week 4 NFL best bets from a model on a 139-103 run on its top-rated picks, and find out.